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Are testosterone replacement products safe?

Testosterone is the hormone responsible for the development of male reproductive tissue and male characteristics such as increased muscle and body hair. Testosterone levels peak when men are in their 20s and gradually decline after the age of 30. As testosterone levels decline, men may experience symptoms such as reduced sex drive, decreased energy, loss of body hair, reduced muscle mass, moodiness, and depression. Other causes of low testosterone include injury, illness, chemotherapy, stress, and alcoholism.

Low testosterone is treated with testosterone replacement therapy. Testosterone products can reduce the side effects of low testosterone and make men look and feel younger. Testosterone replacement products are available as tablets, pellets, creams, gels, patches, and injections.

Popular Brands of Testosterone Treatments

  • Tablets: Striant (Auxilium Pharmaceuticals)
  • Pellets: Testopel (Auxilium Pharmaceuticals)
  • Creams: Axiron (Lilly USA, LLC),
  • Gels: AndroGel (Abbvie), Bio-T-Gel (Teva Pharmaceuticals), Fortesta (Endo Pharmaceuticals), Testim (Auxilium Pharmaceuticals)
  • Patches: Androderm (Actavis)
  • Injections: Delatestryl (Endo Pharmaceuticals), Depo-Testosterone (Unigen Life Sciences)


Testosterone treatment is effective, but it isn’t safe for everyone. A recent study found that men over 65 who treat low testosterone with testosterone replacement products are twice as likely to suffer a heart attack or stroke as men of similar age who are not using testosterone replacement therapy. The same study found an increased risk of heart attack in younger men with pre-existing cardiovascular conditions.

These aren’t the only side effects associated with testosterone products. Other side effects include problems with urination, swelling of the ankles, swelling of breast tissue, prolonged erections, nausea, stomach pain, fever, loss of appetite, and jaundice. However, the labels on testosterone products warn of these conditions. They do not warn of the increased risk of heart attack and stroke.

Men who have suffered a heart attack, stroke, pulmonary embolism, or other cardiovascular effect while on testosterone therapy may be eligible to take part in a class action lawsuit against the makers of these drugs. Contact Hupy and Abraham to learn if you qualify for compensation for your medical expenses, lost income, and pain and suffering. There is no charge for the consultation.

Jason F. Abraham
Managing Partner, Hupy and Abraham

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